Australian captain Aaron Finch confirmed the XI on Saturday after the team's final practice session ahead of the first in a three-match series to open the summer during the final days of winter.
Instead of Labuschagne, Australia will have bowling options galore, with Marcus Stoinis, Mitchell Marsh, Glenn Maxwell and Cameron Green all named, alongside Mitchell Starc, Adam Zampa and Josh Hazlewood as the three specialist bowlers.
Finch also confirmed a change in the batting order, with Steve Smith moving to number three while Alex Carey comes up to number four, and Mitchell Marsh moves down to number six, having batted at three during Australia's most recent 50-over assignment in Sri Lanka.
"The reasoning behind Marnus is we're just going with an allrounder-heavy side," Finch told reporters on Saturday.
"Two quicks plus Zampa, and Cameron Green as the fourth genuine bowler. And then using Marsh, Stoinis, Maxwell as our fifth bowler effectively.
"It's a way of lengthening our batting, and I think it's important we keep trying to juggle the structure of the team around a little bit over the next little while.
"We don't want to get pigeonholed into playing in one particular structure of team."